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COMPOUND DUAL-RELEASE CAPSULE FORMULATION COMPRISED OF BROMODIHYDROARTEISININ AND FE2+ AGENT
专利权人:
发明人:
申请号:
EP12768645.9
公开号:
EP2711005A1
申请日:
2012.03.31
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Disclosed is a compound dual-release capsule formulation consisting of bromo-dihydroartemisinin and a Fe2+ agent and comprising micropills dissolving in the intestine and micropills for rapid dissolution in the stomach, said micropills dissolving in the intestine consisting of cores of bromo-dihydroartemisinin and pharmaceutically acceptable excipients enrobed in intestinal-release coating, and said rapid-release micropills dissolving in the stomach consisting of Fe2+ agent and pharmaceutically acceptable excipients. The micropills of intestinal-release bromo-dihydroartemisinin and the micropills of rapid-release Fe2+ agent are packaged together in gelatin capsules dissolving in the stomach, thus constituting a dual-release formulation.
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