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CAP-DEPENDENT ENDONUCLEASE INHIBITORS
专利权人:
Ming-Chu Hsu;TaiGen Biotechnology Co., Ltd.
发明人:
Chu-Chung Lin,Hung-Chuan Chen,Chiayn Chiang,Chi-Feng Yen,Ming-Chu Hsu
申请号:
US16251652
公开号:
US20190224198A1
申请日:
2019.01.18
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Provided is a compound of Formula (I) below, or a pharmaceutically acceptable salt, metabolite, or prodrug thereof:wherein: A1 is CR4 or N; A2 is CR5R6 or NR7; A3 is CR5′;R6′; or NR7′;; each of R1, R2, R2′;, R3, R3′;, R4, R5, R5′;, R6, R6′;, R7, and R7′;, independently, is hydrogen, deuterium, halogen, cyano, hydroxyl, carboxyl, amino, formyl, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C1-6 alkylcarbonyl, C1-6 alkyloxycarbonyl, C1-6 alkylamine, C3-20 carbocyclyl, or C3-20 heterocyclyl; or R5 and R6, R5′; and R6′;, or R5 and R5′;, together with the adjacent atom to which they are each attached, form C3-10 carbocyclyl or C3-10 heterocyclyl. Further provided are a method of using the above-described compound, or the pharmaceutically acceptable salt, metabolite, or prodrug thereof for treating influenza and a pharmaceutical composition containing same.
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