Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
发明人:
Song Li,Chunsheng Gao,Wu Zhong,Yuli Wang,Meiyan Yang,Li Shan,Xinbo Zhou,Zhibing Zheng,Xiaokui Wang
申请号：
US14386148
公开号：
US09421188B2
申请日:
2013.03.20
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides a combination product, which comprises immediate release pellet of phentermine and sustained-release pellet of topiramate, wherein the pellet of topiramate includes: a) a blank pellet core； b) an active drug layer that contains topiramate and is free of binding agent, the layer being located on surface of the blank pellet core； c) a sustained-release coating layer containing ethyl cellulose and PVP K30, the sustained-release coating layer being located on external of the active drug layer. The present invention further discloses a method for preparing the combination product.
