Quinazolinone derivatives as PARP inhibitors

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专利权人:

Merck Patent GmbH

发明人:

DORSCH, Dieter,BUCHSTALLER, Hans-Peter

申请号：

ES13756318

公开号：

ES2654464T3

申请日:

2013.08.27

申请国别(地区):

ES

年份:

2018

代理人:

摘要：

Compounds selected from group No. Name "A1" 6-fluoro-2- [4- (1-hydroxy-1-methyl-ethyl) -phenyl] -3H-quinazolin-4-one "A2" 2- [4- ( 1-hydroxy-1-methyl-ethyl) -phenyl] -8-methoxy-3H-quinazolin-4-one "A3" 8-fluoro-2- [4- (1-hydroxy-1-methyl-ethyl) -phenyl ] -3H-quinazolin-4-one "A4" 5-fluoro-2- [4- (1-hydroxy-1-methyl-ethyl) -phenyl] -3H-quinazolin-4-one "A5" 6-chloro- 2- [4- (1-Hydroxy-1-methyl-ethyl) -phenyl] -3H-quinazolin-4-one "A6" 8-chloro-2- [4- (1-hydroxy-1-methyl-ethyl) -phenyl] -3H-quinazolin-4-one "A7" 6-fluoro-2- {4- [1- (2-hydroxy-ethoxy) -1-methyl-ethyl] -phenyl} -3H-quinazolin-4- one "A11" 6,8-difluoro-2- [4- (1-hydroxy-1-methyl-ethyl) phenyl] -3H-quinazolin-4-one "A12" 5,6-difluoro-2- [4- (1-hydroxy-1-methyl-ethyl) phenyl] -3H-quinazolin-4-one "A13" 6-fluoro-2- [5- (1-hydroxy-1-methyl-ethyl) -2-pyridyl] - 3H-quinazolin-4-one "A14" 2- [4- (1-ethyl-1-hydroxy-propyl) phenyl] -6-fluoro-3H-quinazolin-4-one "A16" 6-fluoro-2- [ 4- (1-hydroxycyclopentyl) phenyl] -3H-quinazolin-4-one "A17" 6-fluoro-2- [4- (3-hydroxyoxetan-3-yl) phenyl] -3H-quinazolin-4-one "A18 "2- [4- [1 - (2-aminoethoxy) -1-methyl-ethyl] phenyl] -6-fluoro-3H-quinazolin-4-one "A19" 6-fluoro-2- [4- (4-piperidyl) phenyl] -3H-quinazolin -4-one "A21" 6-fluoro-2- {4- [1- (2-hydroxy-ethoxy) -1-methyl-ethyl] -phenyl} -8-methyl-3H-quinazolin-4-one "A23 "5-Chloro-2- [4- (1-hydroxy-1-methyl-ethyl) -phenyl] -3H-quinazolin-4-one" A24 "2- [4- (1-hydroxy-1-methyl-ethyl ) -phenyl] -8-methyl-3H-quinazolin-4-one "A25" 6-fluoro-2- [4- (1-hydroxy-1-methyl-ethyl) -phenyl] -8-methyl-3H-quinazolin -4-one "A26" 5,6,8-trifluoro-2- [4- (1-hydroxy-1-methyl-ethyl) -phenyl] -3H-quinazolin-4-one "A27" 5,8-difluoro -2- [4- (1-Hydroxy-1-methyl-ethyl) -phenyl] -3H-quinazolin-4-one "A29" 6-fluoro-2- [4- (4-hydroxy-piperidin-1-yl ) -phenyl] -8-methyl-3H-quinazolin-4-one "A31" 6-fluoro-2- [4- (4-hydroxymethyl-piperidin-1-yl) -phenyl] -8-methyl-3H-quinazolin -4-one "A32" 6-fluoro-8-methyl-2- [4- (4-methyl- [1,4] diazepan-1-yl) -p

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