作爲二肽基肽酶１抑制劑之特定（２Ｓ）－Ｎ－［（１Ｓ）－１－氰基－２－苯基乙基］－１，４－氧氮雜環庚烷－２

发明人:: LONN, HANS ROLAND,隆恩　汉斯Ｒ,隆恩　漢斯Ｒ,CONNOLLY, STEPHEN,康诺里　史帝芬,康諾里　史帝芬,PONTEN, JOHN FRITIOF,庞腾　约翰Ｆ,龐騰　約翰Ｆ,PO KARLSSON, STAFFAN,波卡尔森　史蒂芬,波卡爾森　史蒂芬,PALMER, NICHOLAS,帕尔玛　尼可拉斯,帕爾瑪　尼可拉斯,SWALLOW, STEVEN,史瓦洛　史帝芬,史,隆恩汉斯R,隆恩漢斯R,康诺里史帝芬,康諾里史帝芬,庞腾约翰F,龐騰約翰F,波卡尔森史蒂芬,波卡爾森史蒂芬,帕尔玛尼可拉斯,帕爾瑪尼可拉斯,史瓦洛史帝芬

摘要：: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD) , to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.本揭示係有關於抑制二肽基肽酶1(DPP1)活性之某些(2S)-N-[(1S)-1-氰基-2-苯基乙基]-1,4-氧氮雜環庚烷-2-甲醯胺化合物(包括其之藥學上可接受的鹽類)，，有關於其等於治療及/或預防臨床病況之用途，包括呼吸性疾病例如氣喘及慢性阻塞性肺臟疾病(COPD)，有關於其等於療法之用途，有關於包含其等之藥學組成物，以及製備此等化合物的方法。