THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人:
申请号：
EP08754714.7
公开号：
EP2170314B1
申请日:
2008.05.23
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
Provided herein are methods for treating a subject suffering from phenylketonuria by administering a phenylalanine hydroxylase ("PAH") and/or a phenylalanine ammonia lyase ("PAL") to the subject under conditions effective to deliver the phenylalanine 4-hydroxylase and/or PAL to the subject's small intestine. Also provided are methods for increasing the therapeutic activity of a phenylalanine 4-hydroxylase by thiolating the phenylalanine 4-hydroxylase. In addition, provided are oral dosage forms that include a phenylalanine 4-hydroxylase and/or a PAL and an enteric coating.
