KOEFFLER, H., PHILLIP,LIU, GEORGE, Y.,THOENNISSEN, NILS,KYME, PIERRE,GOMBART, ADRIAN, F.
申请号：
EP11772654
公开号：
EP2563361A4
申请日:
2011.04.20
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention demonstrates the important role of C/EBP&egr； in innate immune response against pathogens. Specifically, the inventors showed that in the absence of functional C/EBP&egr；, mice are severely impaired in their ability to clear S. aureus infection. Neutrophils are particularly affected, and susceptibility to S. aureus can be rectified by treatment with interferon-gamma (IFN-&gamma；). Importantly, increased activity of C/EBP&egr；, either by induced overexpression of C/EBPE or by application of nicotinamide or an analog, derivative or salt thereof, dramatically enhances immune killing of S. aureus and leads to amelioration of infection.
