The present invention relates to novel hepcidin antagonists of formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anaemias, in particular anaemias in connection with chronic inflammatory diseases (ACD: anaemia of chronic disease and AI: anaemia of inflammation).本發明係有關於具化學式(I)的新穎鐵調素拮抗劑、包含其等的藥學組成物及其作為用於治療鐵質代謝失調症的藥劑之用途,尤其諸如缺鐵性疾病與貧血之鐵質代謝失調症,尤其與慢性發炎性疾病相關連之貧血(ACD:慢性病貧血及AI:炎症貧血)。
