A patient care room and method of treating a patient in a patient care room includes a patient treatment area that is configured to accept a patient support, such as a bed, and a waste containment room that is walled from said treatment area. The waste containment room has a toilet and a door that selectively separates the waste containment area from the treatment area and a decontaminating unit. The decontaminating unit is capable of killing common pathogens. An airflow system discharges air from the waste containment room to outside of the patient care room thereby creating a negative pressure in the waste containment room with respect to the treatment area.