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Optical determination of glucose utilizing boronic acid adducts
专利权人:
Bakthan Singaram
发明人:
Bakthan Singaram,Ritchie A. Wessling
申请号:
US12189094
公开号:
US08951503B2
申请日:
2008.08.08
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.
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