Peter KUFER,Tobias Raum,Roman Kischel,Ralf Lutterbüse,Patrick Hoffmann,Matthias Klinger,Doris Rau,Susanne Mangold
申请号：
US13408363
公开号：
US20120244162A1
申请日:
2012.02.29
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to a polypeptide comprising a first human binding domain capbable of binding to an epitope of human and non-chimpanzee CD3ε (epsilon) chain and a second binding domain capable of binding to EGFR, Her2/neu or IgE of a human and/or a non-chimpanzee primate as well as to a process for the production of the mentioned polypeptide. The invention further relates to nucleic acid sequences encoding the polypeptide, to vectors comprising the nucleic acid sequences and to host cells comprising the nucleic acid sequences or vectors containing the nucleic acid sequences. In another aspect, the invention provides for a pharmaceutical composition comprising the polypeptide and methods of medical treatment or use of the polypeptide.
