Provided herein are methods, compositions and uses involving immunotherapies, such as adoptive cell therapy, e.g., T cell therapy, and inhibitors of a TEK family kinase, such as BTK or ITK. The provided methods, compositions and uses include those for combination therapies involving the administration or use of one or more such inhibitor in conjunction with another agent, such as an immunotherapeutic agent targeting T cells, such as a therapeutic antibody, e.g., a multispecific (e.g., T cell engaging) antibody, and/or genetically engineered T cells, such as chimeric antigen receptor (CAR)-expressing T cells. Also provided are methods of manufacturing engineered T cells, compositions, methods of administration to subjects, nucleic acids, articles of manufacture and kits for use in the methods. In some aspects, features of the methods and cells provide for increased or improved activity, efficacy, persistence, expansion and/or proliferation of T cells for adoptive cell therapy or endogenous T cells recruited by immunotherapeutic agents.L'invention concerne des méthodes, des compositions et des utilisations impliquant des immunothérapies, telles que la thérapie cellulaire adoptive, p. ex., thérapie cellulaire T, et des inhibiteurs d'une kinase de la famille TEK, telle que BTK ou ITK. Les méthodes, compositions et utilisations selon l'invention comprennent celles destinées aux polythérapies impliquant l'administration ou l'utilisation d'un ou plusieurs de ces inhibiteurs conjointement avec un autre agent, tel qu'un agent immunothérapeutique ciblant les cellules T, comme un anticorps thérapeutique, p. ex., un anticorps multispécifique (p. ex., qui recrute des cellules T), et/ou des cellules T génétiquement modifiées, telles que des cellules T exprimant un récepteur d'antigène chimérique (CAR). Des procédés de production de cellules T modifiées, des compositions, des méthodes d'administration à des sujets, des acides nucléiques, des articles manufacturés et des kits utili
