LABÉGUÈRE FRÉDÉRIC GILBERT,NEWSOME GREGORY JOHN ROBERT,ALVEY LUKE JONATHAN,SANIÈRE LAURENT RAYMOND MAURICE,FLETCHER STEPHEN ROBERT,SANIÈRE LAURENT RA
申请号：
PL12812237
公开号：
PL2794604T3
申请日:
2012.12.20
申请国别(地区):
PL
年份:
2017
代理人:
摘要：
A compound according to Formula la: wherein L 1 , G, and R 1 are as decribed herein. The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (IBD), rheumatoid arthritis, vasculitis, lung diseases (e.g. chronic obstructive pulmonary disease (COPD) and lung interstitial diseases (e.g. idiopathic pulmonary fibrosis (IPF))), neuroinflammatory conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.
