Formulation comprising or deriving from an initial blood composition rich in platelets and/or growth factors and proteins originating from the actual initial blood composition wherein said proteins are in a gel state. Also claimed is a method for the preparation of said formulation which comprises the steps of heating and subsequently cooling the initial blood composition to specific temperatures and for specific periods of time. Amongst other advantages the formulation according to the invention is biocompatible and biodegradable exhibits the desirable biological or medical properties afforded by the presence of platelets or growth factors and also exhibits a high level of dimensional stability over time.