A handheld biopsy device (10) comprises a needle (20), cutter (50), and body (30). The cutter is movable relative to the needle to sever tissue protruding into a transverse aperture (24) of the needle. The body includes a cutter actuation mechanism (60), at least two trigger buttons (302,304), and a control module (330). The biopsy device is configured such that the at least two trigger buttons are selectively enabled and disabled. A selectively enabled trigger button is operable to activate the cutter actuation mechanism. A selectively disabled trigger button is not operable to activate the cutter activation mechanism. The enabled trigger button may be selected electronically, such that the control module receives a user's button selection input and enables or disables the trigger buttons accordingly. Alternatively, the body may include movable covers (350) to selectively cover or expose trigger buttons in accordance with the user's preference. The biopsy device may thus accommodate different operators having different gripping styles.
