JOHN HYNES,SATHEESH KESAVAN NAIR,JOHN V. DUNCIA,HONG WU,VENKATRAM REDDY PAIDI,JOSEPH B. SANTELLA,DANIEL S. GARDNER
申请号：
ARP160101892
公开号：
AR105113A1
申请日:
2016.06.23
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Claim 1: a compound characterized by the formula (1) or a Salt that, where a heteroaryl: Het is selected pirrolo [2,3-b] pyridinyl, pirrolo [2,3-d] pirimidinilo, pyrazolo [3,4-b] pyridinyl, pyrazolo [3,4-d] pirimidinilo, imidazolo [4,5 - (b imidazolo pyridinyl] and [4,5-d] P Irimidinilo,Where's the heteroaryl pyridinyl joined the group in the compound of the formula (1) through a Ring nitrogen Atom in the heteroaryl heteroaryl, and where replaced with 0 to 2 r u1d47； is pirazolilo, imidazolilo, triazolilo, isoxazolilo, oxadiazolilo or dihidroisoxazolilo, Each r u00b3 is replaced with r u1d43； c u2082 u208b u2083 alkyl, c u2082 u208b u2083 fluoroalquilo,C u2083 u208b u2084 hidroxialquilo or a cyclic Group Selected c u2083 u208b u2086 cycloalkyl, oxetanilo, tetrahidrofuranilo, tetrahidropiranilo and pirazolilo, where the cyclic Group is replaced with 0 to 2 substituents selected regardless of F, Oh, and ch u2082chf u2082 r u1d43 c u2081 u208b u2082 alkyl； and S: (i) h, F, CL, Oh, - CN, c u2081 u208b u2086 alkyl, c u2081 u208b u2086 fluoroalquilo, c u2081 u208b u2084 cianoalquilo, c u2081 u208b u2086 hidroxialquilo,C u2081 u208b u2085 hydroxy fluoroalquilo, c u2082 u208b u2084 alquenilo, c u2081 u208b u2086 aminoalquilo, - ( u2081 u208b u2083nhr u02b8 ch u2082), - (ch u2082) u2081 u208b u2083nr u02b8r u02b8, ch u2082ch - (OH) (phenyl), CH (ch u2082oh) (phenyl) - ch u2082ch ch u2082 (OH) (phenyl) - ch u2082ch (OH) ch u2082o (metoxifenilo), ch u2082ch (nh u2082 ch u2082) (phenyl) - ( u2084h ch u2082ch u2082o), - ( u2081 u208b ch u2082) u2083o (c u2081 u208b u2083 alkyl) - ch u2082ch (OH) ch u2082o (c u2081 u208b u2083 alkyl) - ch u2082c (OR) (c u2081 u208b u2083 alkyl) - (OR) - (ch u2082c nr u02b8r u02b8 u2081 u208b u2083nr u02b8c ch u2082) (o) (c u2081 u208b u2083 alkyl) - ch u2082c (OR) or (c u2081 u208b u2083 alkyl, - C (o) nh u2082,Ch u2082nr u02b8c - (OR) - (nh u2082, ch u2082 u2081 u208b u2082nr u02b8c () or () or c u2081 u208b u2082 - (alkyl), cr u02b8r u02b8)
