The invention provides a composition and pharmaceutical formulation including a peptide immobilized in a hydrogel. Compositions and formulations of the invention are useful in reducing the size, severity or duration of a wound, ameliorating of one or more symptoms associated with a wound without necessarily curing the wound or lessening in the growth or severity of a wound, skin irritation or skin inflammation. Compositions and formulations of the invention are particularly useful in the treatment of skin irritation, skin inflammation, and a wound associated with diabetes, such as a diabetic ulcer.
