The present invention discloses a method of adjusting snoring mouthpiece, it includes the following procedures: reading first medical image; constructing first respiratory model; commencing first simulation; reading second medical image; constructing second respiratory model; commencing second simulation; calculating adjustment distance value; and adjusting snoring mouthpiece. With the implementation of the present invention, 2 different models and simulations can be established by reading two different respiratory images of a patient, an exact adjustment distance value can be obtained thereafter to rapidly and accurately provide an effective snoring mouthpiece to the patient.本發明為睡眠呼吸牙套之調整方法,其包括下列步驟:讀取第一次醫療影像;建立第一次呼吸道模型;進行第一次呼吸模擬;讀取第二次醫療影像;建立第二次呼吸道模型;進行第二次呼吸模擬;計算調整距離;以及調整睡眠呼吸牙套。藉由本發明之實施,分兩次讀取病人之呼吸道斷層影像,即可依據建立之模型及進行呼吸模擬之結果,提供正確的睡眠呼吸牙套之調整距離並據以進行調整睡眠呼吸牙套,快速且正確地提供給病人確實又有效的睡眠呼吸牙套。