LES LABORATOIRES SERVIER;COMMISSARIAT A L'ENERGIE ATOMIQUE
发明人:
OGIER, JULIEN,DORIS, ERIC,LEFOULON, FRANCOIS,ARNAULD, THOMAS
申请号：
ES09738359
公开号：
ES2378283T3
申请日:
2009.04.28
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Polymerized micelles characterized in that they comprise polymerized amphiphilic molecules obtained from amphiphilic molecules of the general formula AXBLZ where A represents CH3- (CH2) mC = CC = C- (CH2) n- or CH2 = CH- or CH2 = CH-C6H4-, where n and integers are from 1 to 16 identical or different； X represents CO-NH or NH-CO or a link, X is a link if B is a link and L is a link； B represents - (CH2) m-C = C-C = C- (CH2) n- or -CH = CH-C6H4- or a bond, where n and m are whole numbers from 1 to 16 identical or different； L represents - (CH2) r-CH [NH-CO-A '] - or a bond, where r is an integer from 1 to 16 and A' represents A； Z represents s being an integer from 1 to 16, with R2 COOH or SO3H or OSO3H or OPO3H2 or OPO2H2； with R1 H or a COOH or SO3H or OSO3H or OPO3H2 or OPO2H2 group or a group -CO-NH- (CH2) t-CH3, where t is an integer from 1 to 16, or Z can also be a neutral hydrophilic polar head of the sugar or polysaccharide type, as well as its addition salts of a pharmaceutically acceptable acid or base.Micelas polimerizadas caracterizadas porque comprenden moléculas anfífilas polimerizadas obtenidas a partir de moléculas anfífilas de fórmula general A-X-B-L-Z donde A representa CH3- (CH2) m-C=C-C=C- (CH2) n- o CH2=CH- o CH2=CH-C6H4-, siendo n y m números enteros de 1 a 16 identicos o diferentes； X representa CO-NH o NH-CO o un enlace, X es un enlace si B es un enlace y L es un enlace； B representa - (CH2) m-C=C-C=C- (CH2) n- o -CH=CH-C6H4- o un enlace, siendo n y m números enteros de 1 a 16 identicos o diferentes； L representa - (CH2) r-CH[NH-CO-A']- o un enlace, siendo r un numero entero de 1 a 16 y A' representa A； Z representa siendo s un numero entero de 1 a 16, con R2 COOH o SO3H u OSO3H u OPO3H2 u OPO2H2； con R1 H o un grupo COOH o SO3H u OSO3H u OPO3H2 u OPO2H2 o un grupo -CO-NH- (CH2) t-CH3, siendo t un número entero de 1 a 16, o Z puede ser tambien una cabeza polar hidrofila neutra de tipo azucar o polisacarido, así como sus sales de adición de un á
