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Methods and compositions for cns delivery of iduronate-2-sulfatase
专利权人:
SHIRE HUMAN GENETIC THERAPIES INC
发明人:
ZHU GAOZHONG,LOWE KRIS,SHAHROKH ZAHRA,PAN JING,WRIGHT TERESA LEAH,CALIAS PERICLES,FAHRNER RICK,CHRISTIAN JAMES
申请号:
NZ70280811
公开号:
NZ702808A
申请日:
2011.06.25
申请国别(地区):
NZ
年份:
2016
代理人:
摘要:
Disclosed is the use of an iduronate-2-sulfatase (I2S) protein in the manufacture of a formulation for the treatment of Hunters Syndrome, wherein treatment includes intrathecal administration of the formulation to a subject in need of treatment, wherein the formulation comprises an iduronate-2-sulfatase (I2S) protein at a concentration at or greater than about 5 mg/ml, and wherein the formulation comprises no greater than 50 mM of phosphate.
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