BENTLEY, MICHAEL, D.,VIEGAS, TACEY, X.,GOODIN, RICHARD, R.,CHENG, LIN,ZHAO, XUAN
申请号：
DK04814802
公开号：
DK1694363T3
申请日:
2004.12.16
申请国别(地区):
DK
年份:
2014
代理人:
摘要：
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.
