The present disclosure presents sanitization devices and methods. More particularly, the disclosure presents devices and methods that significantly reduce or eliminate the activity of germs, bacteria and/or other infectious microorganisms from objects such as TV remotes, cell phones, electronic devices and personal and other handheld devices. The devices and methods use a pre-cleaning component to substantially remove radiation blocking debris allowing the germicidal radiation to exposes areas of the object that would not be exposed if the debris had not been removed allowing for improved sanitization.