Martha Hayden-Ledbetter;Ingegerd Hellstrom;Jeffrey A. Ledbetter
发明人:
Ingegerd Hellstrom,Jeffrey A. Ledbetter,Martha Hayden-Ledbetter
申请号：
US12536975
公开号：
US09090712B2
申请日:
2009.08.06
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of HE4a polypeptides, including HE4a that is overexpressed in ovarian carcinomas. In particular the invention provides a nucleic acid sequence encoding HE4a, and also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a HE4a polypeptide with a molecule naturally occurring in soluble and/or cell surface form in a sample from such a subject, and by hybridization screening using an HE4a nucleotide sequence, as well as other related advantages.
