North Carolina State University;Northwestern University
发明人:
Todd R. Klaenhammer,Erika Pfeiler,Mansour Mohamadzadeh
申请号：
US15097524
公开号：
US09980992B2
申请日:
2016.04.13
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods and compositions for treating or preventing inflammatory disorders are provided. The compositions of the invention comprise a recombinant bacterium genetically modified to decrease the display of lipoteichoic acid on the cell surface. Methods of the invention comprise administering to a subject a recombinant bacterium modified to decrease the display of lipoteichoic acid on the cell surface. Administration of the recombinant bacterium promotes a desired therapeutic response. The recombinant bacterium may be administered in a single dose or series of doses. Methods of the invention find use in treating or preventing a variety of inflammatory disorders including, for example, treating or preventing inflammatory bowel disease, colitis, or Crohn's disease.
