ХОНГ Килунг (US),ДРЮММОНД Дэрил С. (US),КИРПОТИН Дмитрий В. (US)
申请号：
RU2011112461/15
公开号：
RU2011112461A
申请日:
2011.04.01
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. The composition, which is a liposome in the medium, having an inner space separated from the medium by a membrane comprising one or more lipids, the inner space of the liposome containing a cationic antineoplastic therapeutic agent, as well as a polyol or sugar, polyanionized with at least two strongly anionic functional groups, the sugar being a monosaccharide or disaccharide； in which the cationic substance and the polyanionized polyol or polyanionized sucrose are in the form of an acid or salt, and are also contained within the liposome, which is a parenteral dosage form. ! 2. The composition according to claim 1, in which at least one of the strongly basic functional groups is sulfuric acid ester, phosphoric acid ester, boric acid ester, sulfonic acid group, phosphonic acid group, thiocarboxylic acid group or dithiocarboxylic acid group. ! 3. The composition according to claim 1, in which the monosaccharide is selected from the group consisting of arabinose, ribose, xylose, glucose, galactose, sorbose and fructose, the disaccharide is selected from the group consisting of maltose, sucrose, lactose and trehalose, and the polyol is selected from a group consisting of ethylene glycol, propylene glycol, glycerol, threitol, erythritol, pentaerythritol, ribitol, arabitol, sorbitol, mannitol, lactitol, maltitol, fructitol, glucitol, xylitol or inositol. ! 4. The composition according to claim 1, in which the polyanionized sucrose is a sucrose octasulfate having from 3 to 8 sulfate groups per molecule, and the polyanionized sucrose is an inositol polyphy1. Композиция, представляющая собой липосому в среде, имеющую внутреннее пространство, отделенное от среды мембраной, включающей один или несколько липидов, причем внутреннее пространство липосомы содержит катионный антинеопластический терапевтическоий агент, а также полиол или сахар, полианионизированный с помощью, по меньшей мере, двух сильноанионных функциональных групп, причем сахар представляет собой моносахарид
