Leamon, Paul Christopher,Wang, Yu,Vlahoh, Iontcho Radoslavov
申请号:
AU2016204030
公开号:
AU2016204030A1
申请日:
2016.06.16
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
#$%^&*AU2016204030A120160707.pdf#####BINDING LIGAND LINKED DRUG DELIVERY CONJUGATES OF TUBULYSINS Abstract 100 1400 1200 Tumor 1000 Volumne goo I (rMM-1) WO 7 22 37 52 67 82 97 PT (days) Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations. The compounds described herein include conjugates of tubulysins and vitamin receptor binding ligands. The conjugates also include a releasable bivalent linker. (7315732 1):KZA