LAPPE, Susan E.,PHILLIPS, Darren C.,HILL, Oliver,THIEMANN, Meinolf,GIEFFERS, Christian,BUCHANAN, Fritz G.
申请号：
PE0020162016
公开号：
PE02992017A1
申请日:
2015.04.23
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Refers to a Protein receptor agonist related apoptosis Inducing ligand (Trail), tumor necrosis factor, characterized in that it comprises a polypeptide which has an Amino Acid Sequence SEQ ID no 19 that includes three domains of soluble Trail and a fragme Nto FC. It also relates to a composition.This Protein does not form Aggregates substantially and are appropriate for Therapeutic applications such as Cancer TreatmentSe refiere a una proteina agonista de los receptores de ligando inductor de apoptosis relacionado con el factor de necrosis tumoral (TRAIL) caracterizada porque comprende un polipeptido que tiene una secuencia de aminoacidos de SEQ ID N° 19 que comprende tres dominios de TRAIL solubles y un fragmento Fc. Tambien se refiere a una composicion. Dicha proteina no forma agregados de forma sustancial y son apropiadas para aplicaciones terapeuticas tal como el tratamiento de cancer
