The cell population which includes the tree-like cell to which this invention can be used in order to prescribe to the individual which possesses the tumor partly matures is offered. Taking in the tumor antigen which to the territory of the tumor region is efficiently processing it does the tree-like cell (tree-like cell maturity factor tree-like cell which above approximately 1 hours - approximately 10 hours was contacted) which, matures partly, completes maturity, after that, it can move the lymph node of the individual which was dealt with. Once, when it goes in the lymph node, now the antigen presentation tree-like cell which matures completely, secretes appropriate sight Cain (for example, TNF and IL-12), and contacts with the T cell, induces substantial anti- tumor immuneresponse.本発明は、腫瘍を有する個体に投与するために使用され得る部分的に成熟した樹状細胞を含む細胞集団を提供する。部分的に成熟した樹状細胞(樹状細胞成熟因子と約1時間~約10時間以上接触された樹状細胞)は、腫瘍部位の領域にある腫瘍抗原を効率的に取り込んでプロセシングし、成熟を完了し、その後、処置した個体のリンパ節を移動し得る。一旦、リンパ節中に入ると、今や完全に成熟した抗原提示樹状細胞は、適切なサイトカイン(例えば、TNFαおよびIL-12)を分泌し、そしてT細胞と接触して、実質的な抗腫瘍免疫応答を誘導する。
