Niketa A. Patel,Robert Pleasants Sparks,Wayne Charles Guida
申请号：
US15151068
公开号：
US20160331746A1
申请日:
2016.05.10
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Various scaffolds of small molecules capable of binding to the active site of sortilin are identified by in silico methods. These scaffolds include norbornene anhydride amino acid adducts, phenyl-amide-acids of benzyl substituted glutaric acids, and 2-substituted 3-oxo-1,2,3,4-tetrahydro-2-quinoxalines. These sortilin ligands increase the uptake of glucose in 3T3L1 cells and can be employed in compositions to increase uptake of glucose for the treatment of diabetic patents.
