Compositions for oral use comprising supramolecular complexes formed by polyanionic polymers and spermidine characterized by a ratio of anionic equivalents raging from 10 1 :1 1 to 10 7 :1 eq/eq, more preferably from 10 2 :1 to 10 4 :1 eq/eq, whose components are linked by non-covalent, ionic interactions for use in the treatment of periodontum and oral mucosae in damaged or senescent conditions.