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MORFOLINYLOBENZOTRIAZYNY DO ZASTOSOWANIA W TERAPII RAKOWEJ
专利权人:
Merck Patent GmbH
发明人:
MEDERSKI, WERNER,FUCHSS, THOMAS,EMDE, ULRICH,BUCHSTALLER, HANS-PETER
申请号:
PL12783121
公开号:
PL2780332T3
申请日:
2012.10.30
申请国别(地区):
PL
年份:
2016
代理人:
摘要:
The invention relates to compounds of the formula (I) in which R1, L and m have the meaning indicated in the claims, and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitization of cancer cells to anticancer agents and/or ionizing radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumors, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I) by reaction of compounds of the formulae (II) and (III) and optionally conversion of a base or acid of the compounds of the formula (I) into a salt thereof.
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中国工程科技知识中心
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