The present invention is related to a use for treating and prevention inflammation and/or allergy related disorder of a composition containing a drug and hyaluronic acid (HA), whereas the HA or the HA mixture as a delivery vehicle can be a formulation including at least two HAs having different average molecular weights. The composition has been demonstrated to be capable of reducing the therapeutic dose of a drug on the treatment and prevention of inflammation related disorders is acute inflammatory disease, chronic obstructed pulmonary disease, coeliac disease, conjunctivitis, otitis, allergic rhinitis, gingivitis, aphthous ulcer, bronchitis, gastroesophageal reflux disease (GERD), esophagitis, gastritis, enteritis, peptic ulcer, inflammatory bowel disease (IBD), Crohn's Disease, irritable bowel syndrome (IBS), intestinal inflammation or allergy, urethritis, cystitis, vaginitis, proctitis, eosinophilic gastroenteritis, or rheumatoid arthritis.本發明係一種用於治療及預防發炎及/或過敏相關病變之組合物，該組合物包含一藥物及玻尿酸(hyaluronic acid,HA)或玻尿酸混合物。該玻尿酸或玻尿酸混合物係做為運輸載體而能成為一包含至少兩個具有不同平均分子量的玻尿酸的劑型。該組合物已被證實在治療及預防發炎相關病變上能減少藥物的使用劑量。該病變係包含急性發炎疾病、慢性阻塞性肺病、腹腔疾病、結膜炎、耳炎、過敏性鼻炎、牙齦炎、口腔潰瘍、支氣管炎、胃食管逆流症(GERD)、食道炎、胃炎、腸炎、消化性潰瘍、炎症性腸疾病(IBD)、克隆氏症、激躁性結腸症(IBS)、腸道發炎或過敏、尿道炎、膀胱炎、陰道炎、直腸炎、嗜酸性腸胃炎或類風濕性關節炎。
