METHODS FOR TREATMENT OF LYMPHOMAS WITH MUTATIONS IN CELL CYCLE GENES

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专利权人:

发明人:

Hans Guido Wendel,Elisa Oricchio

申请号：

US14990577

公开号：

US20160331750A1

申请日:

2016.01.07

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present disclosure identifies a novel subtype of follicular lymphoma (FL) characterized by dysregulation of the cyclin/CDK/RB proliferative pathway. This subtype of FL is associated with increased malignancy and mortality, relative to FL which is not associated with cell cycle dysregulation. Accordingly, this disclosure presents novel methods to subtype FL and stratify patient risk by detection of biomarkers associated with RB inactivation. This disclosure further presents novel therapies for the treatment of FL subtyped by inactivation of RB.

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中国工程科技知识中心

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http://www.ckcest.cn/home/