Hybridomas producing antibody fragments having anti-tumor activity in vivo, and specifically react with hDlk-1 (an anti-hDlk-1 antibody) of the antibody, the antibody, the present invention comprises a drug and the antibody or antibody fragment Pharmaceutical compositions comprising complexes, the antibodies and the like, a tumor therapeutic agent, a tumor angiogenesis inhibitor, a tumor diagnostic agent, method of detecting a tumor, and I will provide a diagnostic kit and / or a detection of the tumor.本発明は、hDlk-1と特異的に反応しin vivoで抗腫瘍活性を有する抗体(抗hDlk-1抗体)、当該抗体の断片、当該抗体を産生するハイブリドーマ、当該抗体又は抗体断片と薬剤との複合体、当該抗体等を含む医薬組成物、腫瘍治療剤、腫瘍血管新生阻害剤、腫瘍診断剤、腫瘍の検出方法、並びに腫瘍の検出用及び/又は診断用キット等を提供する。
