The present invention discloses a use of perillyl alcohol (POH) carbamate in manufacturing a pharmaceutical composition for treating nasopharyngeal carcinoma in a mammal. The pharmaceutical composition includes therapeutically effective amount of perillyl alcohol (POH) carbamate for treating nasopharyngeal carcinoma in a mammal, and the perillyl alcohol (POH) carbamate comprises perillyl alcohol conjugated with temozolomide (TMZ).本發明揭露一種紫蘇醇(POH)胺甲酸酯在製備用於治療哺乳動物鼻咽癌的醫藥組成物之用途。醫藥組成物包含於哺乳動物中治療鼻咽癌的紫蘇醇(POH)胺甲酸酯之治療有效量,且紫蘇醇(POH)胺甲酸酯包含與替莫唑胺(TMZ)共軛的紫蘇醇。