The present disclosure relates to a hermetic tooth cleaning device, and more particularly, to a hermetic tooth cleaning device including: a main body which includes an outer case; a cleaning body which is coupled to the main body, and has an internal fluid conduit formed therein such that at least one nozzle is formed to be opened at one end of the internal fluid conduit, and an accommodating portion is formed at the other end of the internal fluid conduit; a connecting unit which couples the main body and the cleaning body, and has a connecting flow path formed therein, one side fixedly coupled to the main body, and the other side inserted into the accommodating portion; and a first sealing unit which is provided between the cleaning body and the connecting unit, and has a hollow space formed therein, thereby preventing a loss of positive pressure or negative pressure and a leak of gargling water or a cleaning solution by improving sealing performance of a flow path that connects a drive unit and the nozzle.