HOOK, DAVID,RISS, BERNHARD,KAUFMANN, DANIEL,NAPP, MATTHIAS,BAPPERT, ERHARD,POLLEUX, PHILIPPE,MEDLOCK, JONATHAN,ZANOTTI-GEROSA, ANTONIO
申请号：
CA2711529
公开号：
CA2711529C
申请日:
2009.01.16
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention relates to a process for producing NEP inhibitors or prodrugsthereof, in particular NEP inhibitorscomprising a .gamma.-amino-.delta.-biphenyl-.alpha.-methylalkanoic acid, oracid ester, backbone. In detail, the new processes, according to thepresent invention, are ultimately related to the synthesis of intermediates toprepare the above NEP inhibitors, namely compoundsaccording to formula (1), or salt thereof, wherein R1 and R2 are.independently of each other, hydrogen or a nitrogen protectinggroup, and R3 is a carboxyl group or an ester group, preferably carboxyl groupor alkyl ester.
