FARMACEVTSKI SESTAVKI ANTAGONISTOV RECEPTORJA METABOTROPNEGA GLUTAMATA 5 (MGLU5)

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专利权人:

F.Hoffmann-La Roche AG

发明人:

CHATTERJI Ashish,HUANG Jingjun,KOENNINGS Stephanie,LINDENSTRUTH Kai,SANDHU Harpreet K.,SHAH Navnit Hargovindas,SH

申请号：

SI201131039

公开号：

SI2603206T1

申请日:

2011.08.08

申请国别(地区):

SI

年份:

2017

代理人:

摘要：

Pharmaceutical compositions of metabotropic glutamate 5 receptor (mGlu5) antagonists or a pharmacologically acceptable salt thereof are disclosed. The compositions contain the therapeutic active compound with non-ionic polymer and ionic polymer, binder and fillers in matrix tablet. The compositions provide a pH-independent in vitro release profile with NMT 70 % in one hour, NMT 85 % in 4 hour, and NLT 80 % in 8 hours. The compositions are useful for the treatment of CNS disorders, such as Treatment-Resistant Depression (TRD) and Fragile X Syndrome.

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中国工程科技知识中心

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http://www.ckcest.cn/home/