Weight loss can be promoted by introducing a microcatheter into the mid segment or distal portion of a human subjects left gastric artery and delivering, via the microcatheter, a plurality of particles with sizes between 300 and 500 μm into the distal portion of the subjects left gastric artery. The particles cause endovascular flow reduction or interruption in the distal portion of the subjects left gastric artery. The reduced or interrupted blood flow decreases the production of the hormone ghrelin, which reduces the subjects appetite, thereby promoting weight loss.
