GENETIC VARIANTS ON CHR 15Q24 AS MARKERS FOR USE IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF EXFOLIATION SYNDROME AND GLAUCOMA

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专利权人:

DECODE GENETICS EHF

发明人:

THORLEIFSSON, GUDMAR,MAGNUSSON, KRISTINN

申请号：

NZ58213108

公开号：

NZ582131A

申请日:

2008.06.13

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

A method for determining the susceptibility of an individual to an ocular condition selected from exfoliation syndrome and exfoliation glaucoma. The method comprises identifying a polymorphic site within the LOX1 gene or a polymorphic allele of the markers rs1048661 (SEQ ID NO: 106) and rs3825942 (SEQ ID NO: 107) and markers in linkage disequilibrium therewith. The presence of an arginine at position 141 or glycine at position 153 in the LOX1 protein, or the presence of allele G in rs1048661 or allele G in rs3825942 are indicative of increased susceptibility to an ocular condition.

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