in vivoin vivoThe invention encompasses micelle assemblies compositions having micelle assemblies and methods for preparing micelle assemblies and compositions thereof. The invention also encompasses a prolamine protein conjugated to a polymer such as a polyethylene glycol (PEG) chain which conjugates can be used to prepare micelle assemblies. The invention further encompasses methods of encapsulating molecules using the conjugates of the invention. The micelle assemblies can be used for a variety of applications such as treating cancer targeting tumors reducing the toxicity of a drug increasing the efficacy of an encapsulated agent protecting an encapsulated agent against degradation and enhancing the water solubility of a drug or other agent.