The present invention relates to a solid phase pharmaceutical composition comprising one or more pharmaceutically acceptable excipients and an active pharmaceutical ingredient (“API”) which is a compound of formula A1 or A2 or a pharmacologically acceptable salt, solvate or hydrate thereof, wherein the API is not exposed to a basic compound.本發明關於固相醫藥組合物,其包含一種或多種醫藥上可接受之賦形劑及活性醫藥成分(「API」),該活性醫藥成分係式A1或A2之化合物或其醫藥上可接受的鹽、溶劑化物或水合物,其中該API不曝露於鹼性化合物。