DIROCCO, Derek, Paul;WONG, Kwok-Kin;BRIGHAM AND WOMEN'S HOSPITAL;SHARPLESS, Norman, E.;ROBE;G-ZERO THERAPEUTICS;BISI, John, Emerson;STRUM, Jay, Copeland;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
The presently disclosed subject matter relates to methods and compositions for protecting cells and or tissues from damage due to ischemia. In particular, the presently disclosed subject matter relates to the protective action of cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to, or that are at risk of, ischemia.