An undergarment with catheter support which increases comfort and reduces the risk of complications related to placement of indwelling catheter tubing. The undergarment with catheter support generally includes a rear portion, a first panel extending from the rear portion and a second panel extending from the rear portion. The rear portion is adapted to be positioned underneath the buttocks of a patient, with the first and second panels being extended around the legs of the patient before connecting to the rear portion so as to form a unified undergarment configuration. The first and second panels are connected to each other via slot connectors to define a catheter slot through which a catheter tube may be extended. A tube retainer and/or tube adapter may also be utilized to guide the catheter tube out of the undergarment through the catheter slot.
