Multifunctional prostheses which include a prosthesis body having at least one interface wall suitable for interfacing with at least one bone tissue, and which also include a substrate are provided. Advantageously, a first covering comprising first functional groups suitable to form chemical bonds, is applied to said substrate. On the side of the first covering the substrate may include protuberances and/or recesses suitable for promoting the attachment of said first functional groups. A second covering comprising nanostructures may be applied to the first covering, on the side opposite the substrate, and an interface covering comprising molecules may be applied to the second covering on the side opposite the first covering. Second functional groups suitable to form chemical bonds, so as to strengthen the bonds between the second covering and the interface covering may be inserted between the interface covering and the second covering. Methods of making such prostheses are also provided.
