This invention, the nano hybrid of siRNA (small interfering RNA) and the target unique stratified inorganic hydroxide which are the powerful gene remedy medicine, regards the production manner and the medicine constituent for the tumor remedy which contains the aforementioned nano hybrid. The nano hybrid which relates to this invention has formed stratified inorganic hydroxide and the nano hybrid where the target oriented Characteristic polyfunctional basic ligand which can be joined with the tumor marker uniquely is joined, in vivo stability of siRNA improving tumor unique transmission efficiency, relatively low from the fact that the tumor remedy activity of siRNA is shown at the dosage tonnage of concentration, it is possible to utilize widely in remedy of the general-purpose target unique tumor.本発明は、強力な遺伝子治療剤であるsiRNA(small interfering RNA)と標的特異的層状無機水酸化物とのナノハイブリッド、その製造方法及び前記ナノハイブリッドを含有する腫瘍治療用の医薬組成物に関する。本発明に係るナノハイブリッドは、腫瘍マーカーと特異的に結合できる標的志向性多官能基リガンドが結合された層状無機水酸化物とナノハイブリッドをなしており、siRNAの生体内安定性が腫瘍特異的伝達効率を向上させて比較的低濃度の投与量でsiRNAの腫瘍治療活性を示すことから、汎用的な標的特異的腫瘍の治療に広く活用することができる。
