PROCEDES D'AUGMENTATION DE L'EFFICACITE IN VIVO D'OLIGONUCLEOTIDES ET D'INHIBITION DE L'INFLAMMATION CHEZ LES MAMMIFERES AU MOYEN DE 2-AMINO-2'-DEOXYADENOSINE
The invention relates to the use of nucleotide substitutes for increasing thein vivo efficacy of nucleic acid molecules and also for inhibitinginflammation in mammals. More particularly, the present invention relates tothe use of 2'6'diaminopurine (DAP) and analogs thereof per se in anti-inflammatory compositions, and also for preparing nucleic acid moleculeshaving an increased in vivo physiological efficiency and a reduced toxicity ascompared to conventional oligos. The invention is particularly useful for thepreparation of antisense oligonucleotides for treating pulmonary/respiratorydiseases such as cystic fibrosis, asthma, chronic bronchitis, chronicobstructive lung disease, eosinophilic bronchitis, allergies, allergicrhinitis, pulmonary fibrosis, adult respiratory distress syndrome, sinusitis,respiratory syncytial virus or other viral respiratory tract infection andcancer.
