Jordan R. Raphel,Andreina Parisi-Amon,Sarah C. Heilshorn
申请号：
US14261805
公开号：
US20140348894A1
申请日:
2014.04.25
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Engineered protein coatings are provided for medical implants to promote bone regeneration. The coating is an engineered protein containing an elastin-like structural domain (SEQ ID No: 2) and a cell-adhesive domain derived from an extended fibronectin RGD sequence. The surface of the medical implant is covalently and directly bonded to the coating via photoreactive crosslinking through an insertion and/or addition reaction. The engineered protein coating can be applied directly upon fabrication of the implant, which would eliminate applying the coating in the operating room. The engineered protein coating is also customizable and can include biologics to improve performance. Furthermore, the engineered protein coating could also be spatially patterned on the implant surface.
