The present invention relates to tyrosine kinase inhibitors that contain a zinc-binding moiety and their use in the treatment of tyrosine related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.本發明係關於一種含鋅結合位之酪胺酸激酶抑制劑,並關於其使用在治療酪胺酸相關疾病及病症,例如癌症。該衍生物尚可作用為HDAC抑制劑。