The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.本揭示案概言之係關於包括抗體之組合物，該等抗體例如單株、嵌合、人類化抗體、抗體片段等，其特異性結合例如人類CD33或哺乳動物CD33等CD33蛋白內之一或多個表位且具有改良及/或增強之功能特性；及此等組合物在預防、降低風險或治療有需要之個體中之用途。
